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KMID : 0043320110340010147
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Archives of Pharmacal Research
2011 Volume.34 No. 1 p.147 ~ p.152
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Antibacterial activities of macrolactin a and 7-O-succinyl macrolactin a from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus
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Kim Dong-Hee
Kim Hye-Kyung
Kim Kang-Min
Kim Chun-Kyu
Jeong Min-Ho
Ko Chan-Young
Moon Kyung-Ho
Kang Jae-Seon
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Abstract
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The principal objective of this study was to evaluate the antibacterial activities of macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA) generated from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci (VREs) and methicillin-resistant Staphylococcus aureus. The minimal inhibitory concentrations (MICs) of MA and SMA against VREs were 16 and 2∼1 μg/mL, respectively, and the MICs of MA and SMA against methicillin-resistant Staphylococcus aureus were 2 and < 0.25 μg/mL, respectively. Their MIC values were comparable or superior to those of teicoplanin. In evaluating the inhibitory effects of intestinal VRE colonization in mice, the oral MA and SMA effected a rapid inhibition of intestinal VRE colonization in mice, and the intraperitoneal SMA also inhibited VRE colonization, whereas intraperitoneal MA did not.
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KEYWORD
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Macrolactin A, 7-O-succinyl macrolactin A, Vancomycin-resistant enterococci, Methicillin-resistant Staphylococcus aureus, Antibacterial activity
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